No, no, no. Odd-eyed cats are wonderful critters (I have one. I'll take it easy on all and not repost a picture, but there's some in my old blogs.) Now, I have a seal point too (ie, more blue eyes, because a seal point is actually an albino with colored hair.) and see three glowing read and one shining silver eye under my table all the time. I've never seen an odd eyed calico though, she must be a rare surprise.

(George Washington and Tommy Smothers both had odd eyes too, which is even rarer for humans. I'll leave it to you to find significance in that pair with odd pairs.)